Ameliorative Potential of Natural Antioxidants Against Paraquat- Induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster: A Comparative Study
نویسندگان
چکیده
Results: Flies exposed to multiple (sub-lethal) dose of PQ showed movement disorder characteristic of Parkinson’s disease (PD). The four natural antioxidants showed ameliorative effects against PQ neurotoxicity in the sub-acute model as seen in survivability, locomotor activity as well as oxidative stress markers including reactive oxygen species (ROS), lipid peroxidation and the endogenous antioxidant defenses.
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